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Altered Brain Activation in Cognitively Intact Individuals at High Risk for Alzheimer's Disease Neurol 53:1391-1396, Smith,C.D.,et al, 1999 See this aricle in Pubmed Article Abstract The regional patterns of brain activation were similar between groups. However, the high risk group showed areas of significantly reduced activation in the mid- and posterior inferotemporal regions bilaterally during both tasks despite ide ntical naming and letter fluency performance. Cognitively normal individuals at high risk for AD demonstrate decreased brain activation in key areas engaged during naming and fluency tasks. Decreased activation in the high risk group may be a consequenc e of the presence of subclinical neuropathology in the inferotemporal region or in the inputs to that region. If so, these findings provide evidence of a window of opportunity for disease-modifying treatment before the onset of symptomatic AD.

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